6-OAU

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6-OAU

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Cat No: 17687

Biochemicals - Receptor Pharmacology

GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic a...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6-(octylamino)-2,4(1H,3H)-pyrimidinedione

Correlated keywords:

GPR84 agonist G-protein coupled receptor GPR 84 biochemical signal transduction inflammation

Product Overview:
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).{29190} It has insignificant actions at a panel of 69 other receptors, channels, or transporters.{29190} 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.{29190} In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.{29190}

Size	1 mg
Shipping	dry ice
CAS Number	83797-69-7
Molecular Formula	C₁₂H₂₁N₃O₂
SMILES	O=C1NC(NCCCCCCCC)=CC(N1)=O
Molecular Weight	239,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.