ML-299

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ML-299

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Cat No: 17632

Biochemicals - Small Molecule Inhibitors

ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively).{28737} It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel.{28737} ML-299 pe...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]-benzamide

Correlated keywords:

1426916-01-9 inhibitor PLD1 PLD2 ML299 ML 299 CID56593087 CID-56593087 antiviral biochemical cancer phospholipase D signal transduction

Product Overview:
ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively).{28737} It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel.{28737} ML-299 penetrates the central nervous system and is functional in vivo when given intraperitoneally.{28738} As PLD1 and PLD2 have roles in cancer and viral infection, ML-299 has potential applications in oncology and virology.{28738}

Size	500 µg
Shipping	dry ice
CAS Number	1426916-00-8
Molecular Formula	C₂₃H₂₆BrFN₄O₂
SMILES	BrC1=CC=C(C(N[C@@H](C)CN2CCC3(C(NCN3C4=CC(F)=CC=C4)=O)CC2)=O)C=C1
Molecular Weight	489,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.