3,3',5'-Triiodo-L-thyronine

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Cat No: 17598

Biochemicals - Receptor Pharmacology

3,3',5’-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than 3,3',5-triiodo-L-thyronine (I...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine

Correlated keywords:

2820-50-0 70-39-3 reverse T3 rTc 3,3,5-T3 isoliothyronine triiodothyronine L-triiodothyronine biochemical hormone receptor agonist cytoskeletal research signal transduction endocrinology peptide thyroid variant

Product Overview:
3,3',5’-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than 3,3',5-triiodo-L-thyronine (Item No. 16028) and commonly described as inactive.{28789,28791} However, high serum levels of rT3 are found in neonates and in certain conditions.{28795,28793,28790,28792} It reportedly activates TRΔα1, a native form of TRα that lacks a nuclear localization signal and functions in the cytoplasm.{28794} Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons.{28794}

Size	5 mg
Shipping	dry ice
CAS Number	5817-39-0
Molecular Formula	C₁₅H₁₂I₃NO₄
SMILES	IC1=C(O)C(I)=CC(OC2=CC=C(C[C@H](N)C(O)=O)C=C2I)=C1
Molecular Weight	651
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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