Nicardipine (hydrochloride)

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Cat No: 17537

Biochemicals - Ion Channel Modulation

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity.{28535} It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 µM, respectively, a...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester, monohydrochloride

Correlated keywords:

55985-32-5 76093-35-1 76093-36-2 152046-25-8 L-type calcium channel blocker antagonist Ca2+ hypertension angina cardiology dihydropyridine adenosine A3 receptor inhibitor cytochrome P450 CYP3A4 TRPA1 biochemical ion pump inhibit intracellular signaling Lecibral Nicapress Barizin Bionicard Cardene Cardepine Dacarel Lescodil Nerdipina Nicant Loxen RS 69216XX07-0 RS69216XX07-0 RS69216 YC 93 YC93 Nicardal Nicarpin Nicodel Nimicor Perdipina Perdipine Ranvil Ridene Rycarden Rydene Vasodin Vasonase dihydropyridine antihypertension antihypertensive antianginal A1 A2A transient receptor potential TRP

Product Overview:
Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity.{28535} It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 µM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 µM.{28536,27561} Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 µM).{23938}

Size	1 g
Shipping	dry ice
CAS Number	54527-84-3
Molecular Formula	C₂₆H₂₉N₃O₆ • HCl
SMILES	CC1=C(C(C(C(OCCN(CC2=CC=CC=C2)C)=O)=C(N1)C)C3=CC([N+]([O-])=O)=CC=C3)C(OC)=O.Cl
Molecular Weight	516
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.