2',3'-Dideoxyadenosine 5'-tripho

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2',3'-Dideoxyadenosine 5'-triphosphate (lithium salt)

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Cat No: 17460

2',3'-Dideoxyadenosine 5'-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively).{28262,28268,28264} It also blocks, in vitro, mammalian and bacterial DNA...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2',3'-dideoxy-adenosine 5'-(tetrahydrogen triphosphate), lithium salt

Correlated keywords:

24028-04-4 132619-65-9 biochemical inhibitor antiviral infectious disease inhibit in vitro reverse transcriptase retrovirus HIV-1 visna DNA polymerase phosphorylation 2’,3’-dideoxyadenosine 2,3- dATP chain termination dideoxynucleoside 5’-triphosphate terminate extension Taq polymerase reaction antagonist purinergic P2X2/3 24027-80-3

Product Overview:
2',3'-Dideoxyadenosine 5'-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively).{28262,28268,28264} It also blocks, in vitro, mammalian and bacterial DNA polymerases.{28265,28263} ddATP, produced intracellularly by the phosphorylation of exogenously supplied 2’,3’-dideoxyadenosine, competes with dATP, resulting in chain termination.{28265,28263} Because of this activity, dideoxynucleoside 5’-triphosphates, including ddATP, are used to terminate chain extension produced by the Taq polymerase used in polymerase chain reactions.{28266} It is also an antagonist of the purinergic receptor P2X2/3 (pIC50 = 6.5).{28267}

Size	100 µl
Shipping	dry ice
Molecular Formula	C₁₀H₁₆N₅O₁₁P₃ • XLi
SMILES	O=P(OP(OP(O)(O)=O)(O)=O)(O)OC[C@@H]1CC[C@H](N2C=NC3=C2N=CN=C3N)O1.[Li]
Molecular Weight	475,2
Formulation	A 10 mM solution in water
Purity	≥98%
Custom Code	2934.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.