AG957

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AG957

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Cat No: 17259

Biochemicals - Kinase Inhibitors

Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases.{15153} AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 µM,...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[[(2,5-dihydroxyphenyl)methyl]amino]-benzoic acid, methyl ester

Correlated keywords:

biochemical inhibitor kinase protein cancer signal transduction intracellular signaling receptor biochemistry AG-957 NSC654705 Bcr-Abl c-Abl BcrAbl cAbl

Product Overview:
Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases.{15153} AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 µM, respectively, for human proteins).{29184} It also inhibits epidermal growth factor receptor (IC50 = 0.25 µM).{29184} As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line.{29187,29186} AG957 is also used to study signaling through c-Abl.{29185}

Size	1 mg
Shipping	dry ice
CAS Number	140674-76-6
Molecular Formula	C₁₅H₁₅NO₄
SMILES	OC1=C(CNC2=CC=C(C(OC)=O)C=C2)C=C(O)C=C1
Molecular Weight	273,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.