8-pCPT-2'-O-Me-Cyclic AMP (sodiu

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8-pCPT-2'-O-Me-Cyclic AMP (sodium salt)

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Cat No: 17143

Biochemicals - Small Molecule Activators

Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2.{23361} 8-pCPT-2'-O-Me-Cyclic AMP is an 8-(4-chlorophenylthio) analog of cAMP that activates Epacs (AC50 = 1.8 µM).{28115} It...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

?8-[(4-chlorophenyl)thio]-2'-O-methyl-adenosine cyclic 3',5'-(hydrogen phosphate)?, monosodium salt

Correlated keywords:

510774-50-2 1049735-93-4 1022081-00-0 biochemical intracellular signaling cyclic nucleotide cell biology selective super-activator EPAC exchange protein activated guanine nucleotide factor GEF GTPase RAP1 RAP2 8-4-chlorophenylthio analog cAMP kinase PKA EPAC1 EPAC2

Product Overview:
Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2.{23361} 8-pCPT-2'-O-Me-Cyclic AMP is an 8-(4-chlorophenylthio) analog of cAMP that activates Epacs (AC50 = 1.8 µM).{28115} It is a super-activator of Epacs in that it dissociates GDP from Rap1 more strongly than the natural Epac agonist, cAMP.{28115,28118} 8-pCPT-2'-O-Me-cAMP is strongly selective for Epac over the cAMP-activated kinase PKA.{28118} It does not discriminate between Epac1 and Epac2 and is used extensively to elucidate the roles of these Rap GEFs in cell function.{23361,28116,28117,23348}

Size	500 µg
Shipping	dry ice
CAS Number	634207-53-7
Molecular Formula	C₁₇H₁₆N₅O₆ClPS • Na
SMILES	O=P1([O-])O[C@H]2[C@@H](OC)[C@H](N3C(SC4=CC=C(Cl)C=C4)=NC5=C3N=CN=C5N)O[C@@H]2CO1.[Na+]
Molecular Weight	507,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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MSDS

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