Bialaphos (sodium salt)

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Cat No: 16754

Biochemicals - Peptides

Bialaphos is a natural non-selective phytotoxin produced by certain Streptomyces species. It is a pro-toxin, a tripeptide that is converted in vivo to the active agent phosphinothricin, which is a glutamine analog.{27463} L-Phosphinothricin inhibits g...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2S-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine, monosodium salt

Correlated keywords:

35597-43-4 80395-?47-?7 122796-?14-?9 biochemical natural product plant biology inhibitor molecular inhibit herbicide nonselective non-selective phytotoxin Streptomyces species pro-toxin protoxin tripeptide converted in vivo active agent phosphinothricin glutamine analog L-phosphinothricin synthetase accumulation ammonium disruption primary metabolism bacterial bar gene acetyltransferase resistance selection transgenic express viral promoter Bilanafos Herbi-Ace HerbiAce Herbie MW 801 MW801

Product Overview:
Bialaphos is a natural non-selective phytotoxin produced by certain Streptomyces species. It is a pro-toxin, a tripeptide that is converted in vivo to the active agent phosphinothricin, which is a glutamine analog.{27463} L-Phosphinothricin inhibits glutamine synthetase (Ki = 6.1 µM), resulting in accumulation of ammonium and disruption of primary metabolism.{27463,27464} The bacterial bar gene encodes a phosphinothricin acetyltransferase, which confers resistance to phosphinothricin.{27244} Bialaphos is used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter.{27244}

Size	10 mg
Shipping	dry ice
CAS Number	71048-99-2
Molecular Formula	C₁₁H₂₁N₃O₆P • Na
SMILES	[O-]C([C@H](C)NC([C@H](C)NC([C@@H](N)CCP(C)(O)=O)=O)=O)=O.[Na+]
Molecular Weight	345,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.