FTase Inhibitor II (trifluoroace

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FTase Inhibitor II (trifluoroacetate salt)

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Cat No: 16607

Biochemicals - Small Molecule Inhibitors

Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins.{26419,21707} This post-translational modification is crucia...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine, trifluoroacetate salt

Correlated keywords:

156707-43-6 313641-?99-?5 biochemical cancer inhibitor intracellular signaling signal transduction farnesyltransferase farnesyl transferase farnesylation utilization pyrophosphate FPP inhibit potent selective intermediate mevalonate pathway FTase lipid proteins post-translational posttranslational modification target Ras membrane cell-permeable analog block Ras-mediated transformation NIH 373 cell NIH373 H-Cys-4-Abz-Met-OH protein lipidation

Product Overview:
Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins.{26419,21707} This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function at, membranes. FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras.{27760} It does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM).{27760} FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells.{27760}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₁₅H₂₁N₃O₄S₂ • XCF₃COOH
SMILES	O=C(N[C@H](C(O)=O)CCSC)C1=CC=C(NC([C@@H](N)CS)=O)C=C1.FC(F)(C(O)=O)F
Molecular Weight	371,5
Formulation	A crystalline solid
Purity	≥80%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.