N?-(1-Carboxymethyl)-L-lysine

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N^?-(1-Carboxymethyl)-L-lysine

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Cat No: 16483

Biochemicals - Small Molecule Inhibitors

Nε-(1-Carboxymethyl)-L-lysine (CML) is an advanced glycation end product (AGE), produced by the oxidative modification of glycated proteins during oxidative stress.{27118,27121,27119} Levels of CML increase with aging and during diabetes, cancer, vasc...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N6-(carboxymethyl)-L-lysine

Correlated keywords:

oxidative stress diabetes vascular disease aging cancer receptor agonist cardiology atherosclerosis injury biochemical advanced glycation endproduct AGE RAGE sRAGE modification glycated protein activates activator membrane-bound signals signaling MAPKs NF-?B NFKB soluble binds binding reduce reduction N6 Carboxymethyl lysine

Product Overview:
Nε-(1-Carboxymethyl)-L-lysine (CML) is an advanced glycation end product (AGE), produced by the oxidative modification of glycated proteins during oxidative stress.{27118,27121,27119} Levels of CML increase with aging and during diabetes, cancer, vascular disease, and other pathologies marked by oxidative stress.{27118,27116,27115} CML activates the membrane-bound receptor for AGEs (RAGE), triggering signaling through MAPKs and NF-κB, whereas truncation of RAGE produces a soluble protein that binds CML and reduces signaling.{27120,27117}

Size	1 mg
Shipping	dry ice
CAS Number	03/04/5746 00:00
Molecular Formula	C₈H₁₆N₂O₄
SMILES	OC(CNCCCC[C@H](N)C(O)=O)=O
Molecular Weight	204,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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