?-(difluoromethyl)-DL-Arginine

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Cat No: 16415

Bacteria synthesize the cellular growth factor putrescine through a number of pathways. One pathway involves the decarboxylation of arginine by arginine decarboxylase to produce agmatine, which is then degraded to putrescine. While important for variou...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(difluoromethyl)-arginine

Correlated keywords:

polyamines biosynthesis inhibitors plants growths regulators putrescines immunology infectious diseases arginines decarboxylases 77286-88-5 signals transductions cells biology biochemicals DL-?-(Difluoromethyl)arginine ?-Difluoromethylarginine ? enzymes activated enzyme-activated irreversible irreversibly inhibits E Escherichia coli Ecoli P Pseudomonas aeruginosa Paeruginosa K Klebsiella pneumonia Kpneumonia prevents prevention osmotic stress-induced stress induced increases activities activity synthesis oats leaf reduces reductions reduced T Trypanosoma cruzi Tcruzi mammalian mammals hosts C. Cryptosporidium parvum Cparvum T-cells Tcells receptors ?-deficient deficient mouse models polyamines analogs RMI 71897

Product Overview:
Bacteria synthesize the cellular growth factor putrescine through a number of pathways. One pathway involves the decarboxylation of arginine by arginine decarboxylase to produce agmatine, which is then degraded to putrescine. While important for various cellular processes (e.g., cell division, differentiation, environmental stress responses) in all living organisms, including plants, high levels of this polyamine can be toxic.{23742} α-(difluoromethyl)-DL-Arginine (DFMA) is an enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 µM), P. aeruginosa, and K. pneumoniae.{26879} At 0.01 mM, it has been shown to prevent the osmotic stress-induced increase in arginine decarboxylase activity and putrescine synthesis in oat leaf cells.{26875,26878} DFMA can also reduce the growth of T. cruzi in mammalian host cells at a minimal concentration of 10 mM and prevent the growth of C. parvum in a T cell receptor alpha-deficient mouse model when combined with various polyamine analogs.{26877,26876}

Size	1 mg
Shipping	dry ice
CAS Number	69955-43-7
Molecular Formula	C₇H₁₄F₂N₄O₂
SMILES	FC(F)C(C(O)=O)(N)CCCNC(N)=N
Molecular Weight	224,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2905.59
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.