(S)-Ketoprofen

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(S)-Ketoprofen

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Cat No: 16407

Biochemicals - Small Molecule Inhibitors

Ketoprofen (Item No. 10006661) is a non-selective, non-steroidal, anti-inflammatory drug exhibiting IC50 values of 0.5 and 2.33 µM for human recombinant COX-1 and COX-2 (Item No. 60122), respectively.{1286} Ketoprofen is commonly used in vivo as a race...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-benzoyl-?S-methyl-benzeneacetic acid

Correlated keywords:

inhibitor NSAID cyclooxygenase inflammation COX1 COX-1 COX2 COX-2 inhibit rheumatoid arthritis renal diseases anti-inflammatory antiinflammatory non-steroidal nonsteroidal glucuronides biochemical cyclooxygenases arveles (+)-m-benzoyl-hydratropic acid (+)-(S)-m-benzoylhydratropic (+)-2-(3-benzoylphenyl)propionic acid (+)-3-benzoyl-?-methylbenzeneacetic S-(+)-ketoprofen (S)-2-(3-benzoylphenyl)propanoic

Product Overview:
Ketoprofen (Item No. 10006661) is a non-selective, non-steroidal, anti-inflammatory drug exhibiting IC50 values of 0.5 and 2.33 µM for human recombinant COX-1 and COX-2 (Item No. 60122), respectively.{1286} Ketoprofen is commonly used in vivo as a racemic mixture of (R)- and (S)-enantiomers. (S)-Ketoprofen is a potent inhibitor of COX-1 and COX-2 (IC50s = 1.9 and 27 nM, respectively), whereas the (R)-enantiomer is 100 to 1,000 times less potent.{27037,7889} Notably, (S)-ketoprofen is known to be formed from the (R)-enantiomer in several animal species, except in humans and guinea pigs.{7889} Also, the pharmacokinetics of ketoprofen enantiomers and their glucuronide metabolites are altered in humans with rheumatoid arthritis or renal disease.{27035,27036}

Size	100 mg
Shipping	dry ice
CAS Number	22161-81-5
Molecular Formula	C₁₆H₁₄O₃
SMILES	O=C(C1=CC=CC([C@H](C)C(O)=O)=C1)C2=CC=CC=C2
Molecular Weight	254,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2918.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.