SU 1498

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SU 1498

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Cat No: 16354

Biochemicals - Kinase Inhibitors

SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.{26805,23658} It effectively blocks signaling through...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide

Correlated keywords:

197592-?60-?2 1352088-48-2 inhibitors receptors biochemistry signals transduction cancers angiogenesis ophthalmology neurosciences signaling SU1498 SU-1498 inhibits inhibitions selective tyrosine kinases VEGF 2 two VEGFR-2 VEGFR VEGFR2 Flk-1 one Flk1 Flk 1 serine threonine in vitro vivo tumors growth neural progenitor cells neuroregeneration AG 1498 AG1498 AG-1498 tyrphostin

Product Overview:
SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.{26805,23658} It effectively blocks signaling through VEGFR2 both in vitro and in vivo.{26805,26806} SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.{26806,26802,26803,26804}

Size	500 µg
Shipping	dry ice
CAS Number	168835-82-3
Molecular Formula	C₂₅H₃₀N₂O₂
SMILES	O=C(/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1)NCCCC2=CC=CC=C2
Molecular Weight	390,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2837.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.