AAL-993

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AAL-993

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Cat No: 16351

Biochemicals - Kinase Inhibitors

AAL-993 is a potent inhibitor of VEGF receptors, inhibiting VEGFR1, 2, and 3 with IC50 values of 130, 23, and 18 nM, respectively.{26698,26700} It less potently inhibits c-Kit, colony stimulating factor 1 receptor, PGDF receptor β, and EGF receptor (I...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-?[(4-?pyridinylmethyl)?amino]?-?N-?[3-?(trifluoromethyl)?phenyl]?-benzamide

Correlated keywords:

inhibitors angiogenesis cancers signals transductions hypoxia receptors biochemistry inhibits inhibitions VEGF inhibiting VEGFR VEGFR-1 VEGFR1 VEGFR-2 VEGFR2 VEGFR-3 VEGFR3 1 2 3 one two three c-Kit c Kit colony stimulating factors PGDF ? EGF orally bioavailable in vivo blocks VEGF-induced induced prevents growths primary tumors spontaneous peripheral metastases mice hypoxia-mediated increases hypoxia-inducible factor-1 transcriptional activity ERK-dependent ERK dependents manners AAL993 AAL 993 ZK-260253 ZK 260253 potent

Product Overview:
AAL-993 is a potent inhibitor of VEGF receptors, inhibiting VEGFR1, 2, and 3 with IC50 values of 130, 23, and 18 nM, respectively.{26698,26700} It less potently inhibits c-Kit, colony stimulating factor 1 receptor, PGDF receptor β, and EGF receptor (IC50s = 236, 380, 640, and 1,040 nM, respectively) and is without effect on a number of other tyrosine kinases.{26698} AAL-993 is orally bioavailable in vivo, blocks VEGF-induced angiogenesis, and prevents the growth of primary tumors and spontaneous peripheral metastases in mice.{26698,26699} It also inhibits hypoxia-mediated increase in hypoxia-inducible factor-1 transcriptional activity in an ERK-dependent manner (IC50 = ~5 µM).{26701}

Size	1 mg
Shipping	dry ice
CAS Number	269390-77-4
Molecular Formula	C₂₀H₁₆F₃N₃O
SMILES	O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=CC=C2NCC3=CC=NC=C3
Molecular Weight	371,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.