Y320 - C27H29ClN6O2 - Bertin Bioreagent

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Y320

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Cat No: 16314

Biochemicals - More Biochemicals

IL-15 is a pro-inflammatory cytokine with roles in cancer and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, celiac disease, and alopecia areata.{28368} IL-15 can induce IL-17 production by CD4 T cells.{2836...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-?(4-?chlorophenyl)?-?N-?[3-?cyano-?4-?[4-?(4-?morpholinyl)?-?1-?piperidinyl]?phenyl]?-?5-?methyl-1H-?pyrazole-?4-?carboxamide

Correlated keywords:

biochemical receptor antagonist arthritis autoimmune disease cancer inhibitor immunology inflammation inhibit Y-320 IL-15 IL15 mediated CD4 T cell activation CD-4 pro-inflammatory proinflammatory cytokine rheumatoid inflammatory bowel psoriasis celiac alopecia areata IL-17 IL17 joint destruction type II 2 collagen-induced CIA mice model synergistically TNF-? TNF? ameliorating scores swelling cynomolgus monkey

Product Overview:
IL-15 is a pro-inflammatory cytokine with roles in cancer and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, celiac disease, and alopecia areata.{28368} IL-15 can induce IL-17 production by CD4 T cells.{28367} Y320 is an inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15, either alone or in combination with CXCL12 and anti-CD3 monoclonal antibody (IC50s = 57.4 and 25.7 nM, respectively).{28367} Oral administration of Y320 (0.3-3 mg/kg) reduces the expression of inflammatory cytokines, including IL-17, and inhibits joint destruction in type II collagen-induced arthritis (CIA) in mice.{28367} In this model, it acts synergistically with TNF-α monoclonal antibody in ameliorating arthritis and joint destruction scores.{28367} Y320 also significantly reduces joint swelling in cynomolgus monkey CIA.{28367}

Size	1 mg
Shipping	dry ice
CAS Number	288250-47-5
Molecular Formula	C₂₇H₂₉ClN₆O₂
SMILES	O=C(C1=C(C)N(C2=CC=C(Cl)C=C2)N=C1)NC(C=C3)=CC(C#N)=C3N(CC4)CCC4N5CCOCC5
Molecular Weight	505
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.