TCS PIM-1 1

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TCS PIM-1 1

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Cat No: 16286

Biochemicals - Kinase Inhibitors

The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has be...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile

Correlated keywords:

cancer proto-oncogene serine/threonine-protein kinase Pim-1 signal transduction 1413440-43-3 biochemical inhibitor inhibit TCSPIM-11 TCMPIM11 PIM11 ATP-competitive II

Product Overview:
The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor (IC50 = 50 nM) that displays selectivity over the related kinases, Pim-2 and MEK1/2 (IC50s = >20 µM).{28246}

Size	5 mg
Shipping	dry ice
CAS Number	491871-58-0
Molecular Formula	C₁₈H₁₁BrN₂O₂
SMILES	O=C1NC(C2=C(O)C=CC(Br)=C2)=CC(C3=CC=CC=C3)=C1C#N
Molecular Weight	367,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2908.99
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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