PD 0332991 (hydrochloride)

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Cat No: 16273

Biochemicals - Kinase Inhibitors

PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases.{28137} It has been reported to have antiproliferative activity ag...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6-?acetyl-?8-?cyclopentyl-?5-?methyl-?2-?[[5-?(1-?piperazinyl)?-?2-?pyridinyl]?amino]?-pyrido[2,?3-?d]?pyrimidin-?7(8H)?-?one, monohydrochloride

Correlated keywords:

571190-30-2 827022-33-3 571189-11-2 PD 332991 PD332991 PD0332991 highly selective inhibitor inhibit CDK4/6 CDK4 CDK6 CDK-4 CDK-6 Cdk4/cyclin D1 Cdk6/cyclin D2 cyclin dependent kinase cyclinD2 cyclinD1 D-1 D-2 antiproliferative retinoblastoma tumor cell cycle arrest cancer glucose metabolism phosphorylation G1 arrest insulin-activated biochemical biology diabetes intracellular signaling protein signal transduction ?ibrance

Product Overview:
PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases.{28137} It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations.{28137} PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen (Item No. 13258) and trastuzumab, respectively.{28138} PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.{26552}

Size	1 mg
Shipping	dry ice
CAS Number	827022-32-2
Molecular Formula	C₂₄H₂₉N₇O₂ • HCl
SMILES	O=C1N(C2CCCC2)C3=NC(NC4=NC=C(N5CCNCC5)C=C4)=NC=C3C(C)=C1C(C)=O
Molecular Weight	484
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.