ICG-001

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ICG-001

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Cat No: 16257

Biochemicals - Small Molecule Inhibitors

ICG-001 is a small molecule inhibitor of β-catenin/cyclic AMP responsive element binding protein (CREB) binding protein (CBP)-mediated transcription (IC50 = 3 µM).{26952} By binding CBP, thus blocking interaction with β-catenin, it selectively induces...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(6S,9aS)-hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

Correlated keywords:

inhibitors Wnts ?-catenins cyclic AMPs responsive elements bindings proteins binding protein CBP transcriptions cancer pulmonary fibrosis cancers stems cells 847591-62-2 868774-16-7 721457-27-8 1402835-92-0 ICG001 ICG 001 antagonists Wnt/?-catenin Wnt/? catenins ? TCF-mediated TCF mediated binds element-binding inhibits inhibitions intracellular signaling transductions biochemicals research small molecules cyclic AMP cAMP blocks blocking interactions selectively induces induced apoptosis transformed colon prevents prevention growths carcinomas in vitro disrupts disruptions epithelial-mesenchymal epithelial mesenchymal transitions pulmonary fibrosis regulations regulating

Product Overview:
ICG-001 is a small molecule inhibitor of β-catenin/cyclic AMP responsive element binding protein (CREB) binding protein (CBP)-mediated transcription (IC50 = 3 µM).{26952} By binding CBP, thus blocking interaction with β-catenin, it selectively induces apoptosis in transformed colon cells but not in normal cells and prevents the growth of colon carcinoma cells at 25 µM in vitro.{26952,26951} ICG-001 has been used to specifically disrupt the β-catenin pathway in studying epithelial-mesenchymal transition during pulmonary fibrosis.{26949,26953} Additionally, ICG-001 disruption of Wnt/β-catenin signaling has been studied in the context of regulating cancer stem cells.{26950}

Size	1 mg
Shipping	dry ice
CAS Number	780757-88-2
Molecular Formula	C₃₃H₃₂N₄O₄
SMILES	O=C([C@H](CC1=CC=C(O)C=C1)N(C(CCN2C(NCC3=CC=CC=C3)=O)=O)[C@]2([H])C4)N4CC5=CC=CC6=CC=CC=C65
Molecular Weight	548,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.