NQDI-1

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NQDI-1

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Cat No: 16226

Biochemicals - Kinase Inhibitors

Apoptosis signal-regulating kinase 1 (ASK1) is the ubiquitously expressed mitogen-activated protein kinase kinase kinase 5 involved in a wide range of biological functions that are dependent on cell survival or death.{10689,26710} NQDI-1 is a specific ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2,7-dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid, ethyl ester

Correlated keywords:

apoptosis signal-regulating kinases 1 ASK1 mitogen-activated proteins kinase kinase kinase 5 MAP3K5 inhibitors neuroprotective MAP kinase neurons stems cells neurodegeneration signals regulating ASK-1 ASK 1 one mitogens activated transductions research neuroscience intracellular signaling inhibits 3K5 inhibitions NQDI1 NQDI selective specific serine/threonine serines threonines tyrosines survival induced pluripotent populations protects neurons reactive oxygen species-induced species model ischemia

Product Overview:
Apoptosis signal-regulating kinase 1 (ASK1) is the ubiquitously expressed mitogen-activated protein kinase kinase kinase 5 involved in a wide range of biological functions that are dependent on cell survival or death.{10689,26710} NQDI-1 is a specific inhibitor of ASK1 (IC50 = 3 μM; Ki = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein kinases.{26710} It has been used to promote survival of induced pluripotent stem cell populations and to protect neurons from reactive oxygen species-induced apoptosis in a model of ischemia.{26712,26711}

Size	1 mg
Shipping	dry ice
CAS Number	175026-96-7
Molecular Formula	C₁₉H₁₃NO₄
SMILES	O=C(C1=C2C(N3)=CC=C1)C4=CC=CC=C4C2=C(C(OCC)=O)C3=O
Molecular Weight	319,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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