Uric Acid (sodium salt)

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Cat No: 16219

Biochemicals - Ox Stress Reagents

Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase.{26400} The final two steps in its production are catalyzed by xanthine o...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7,9-dihydro-1H-purine-2,6,8(3H)-trione, monosodium salt

Correlated keywords:

69-93-2 NLPR3 inflammation immunology purine metabolism hyperuricemia gout NOD-like receptors proteins 3 inflammasome xanthine oxidase oxidative injury stress antioxidants end product humans excreted urine potent peroxynitrite scavengers serum uric acids gout kidney stones metabolic syndrome hypertension renal cardiovascular diseases cardiology diabetes obesity sodium urate

Product Overview:
Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase.{26400} The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide.{26402} Uric acid acts as a potent peroxynitrite scavenger and antioxidant.{26400,26402,6143} However, high levels of serum uric acid (>120 µg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease.{26400,18377,18381,18380,18379} Uric acid in the form of monosodium urate crystals has been proposed to trigger interleukin-1β-mediated inflammation by activating the NOD-like receptor protein 3 inflammasome.{26401}

Size	2 mg
Shipping	dry ice
CAS Number	1198-77-2
Molecular Formula	C₅H₃N₄O₃ • Na
SMILES	O=C(N1)NC2=C1C([O-])=NC(N2)=O.[Na+]
Molecular Weight	190,1
Formulation	A crystalline solid
Custom Code	2933.59
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.