Juglone

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Juglone

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Cat No: 16216

Biochemicals - Natural Products

Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. It has allelopathic actions, suppressing growth, photosynthesis, and respiration in plants and other organisms, although some bacteri...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-hydroxy-1,4-naphthalenedione

Correlated keywords:

natural products inhibitors inhibits inhibitions genes regulations plants growths regulators biology allelopathic naphthoquinones black walnuts J. J nigra juglandaceae suppresses suppressing growths photosynthesis respiration irreversible irreversibly peptidyl-prolyl peptidyl prolyl cis/trans isomerases parvulin pin1 yeasts ess1/ptf1 ess1 ptf1 E. E coli blocks transcription RNA polymerases I II III 1 2 3 one two three kidneys fibrosis 5-hydroxynaphthoquinone 8-hydroxy-1,4-naphthoquinone akhnot C.I. 75500 natural brown 7 seven nucin regianin extracts NSCs 153189 34266 622948 NSC153189 NSC34266 NSC622948 NSC-153189 NSC-34266 NSC-622948 1,4-dihydro-1,4-dioxo-5-hydroxynaphthalene

Product Overview:
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. It has allelopathic actions, suppressing growth, photosynthesis, and respiration in plants and other organisms, although some bacteria can metabolize juglone.{26429,26432} Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM).{26430} Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 µM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.{26433,26431}

Size	500 mg
Shipping	dry ice
CAS Number	481-39-0
Molecular Formula	C₁₀H₆O₃
SMILES	O=C1C=CC(C2=CC=CC(O)=C21)=O
Molecular Weight	174,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.