Coelenterazine

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Coelenterazine

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Cat No: 16123

Coelenterazine is a luciferin, a light-emitting biomolecule that serves as a substrate for luciferases or as a constituent of photoproteins, including aequorin.{22804} The oxidation of coelenterazine to coelenteramide is accompanied by emission of blu...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-imidazo[1,2-a]pyrazin-3(7H)-one

Correlated keywords:

fluorescent probes intracellular signaling signalling 57683-96-2 luciferin NanoFuel Nano Fuels natives Preluciferin Watasenia Oplophorus light-emitting lights emitting emits emitted biomolecules substrates luciferases photoproteins photo-proteins photo proteins aequorin oxidations coelenteramide emissions blues luciferase-mediated mediated derivatives energy donors forms greens yellows bioluminescent resonance transfers BRET bioluminescence fluorescence studies non-enzymatic nonenzymatic non enzymatic calcium Ca Ca+2 +2 + 2 cellular redox status reductions reactions non-fluorescently nonfluorescently fluorescently levels changes

Product Overview:
Coelenterazine is a luciferin, a light-emitting biomolecule that serves as a substrate for luciferases or as a constituent of photoproteins, including aequorin.{22804} The oxidation of coelenterazine to coelenteramide is accompanied by emission of blue light (emission maximum, 460-470 nm). Luciferase-mediated oxidation of coelenterazine or a derivative is used as an energy donor, typically to a form of green or yellow fluorescent protein, in bioluminescent resonance energy transfer studies.{26296,26290} Alternatively, the calcium-mediated release of coelenterazine from aequorin, followed by non-enzymatic oxidation of this compound, results in bioluminescence. As light emission depends on both calcium and cellular redox status, this reaction is used to non-fluorescently detect changes in calcium level and redox status.{5885,6107}

Size	500 µg
Shipping	dry ice
CAS Number	55779-48-1
Molecular Formula	C₂₆H₂₁N₃O₃
SMILES	OC1=CC=C(C2=CN3C(N=C(CC4=CC=C(O)C=C4)C3=O)=C(CC5=CC=CC=C5)N2)C=C1
Molecular Weight	423,5
Formulation	A crystalline solid
Purity	≥85%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.