GDF11 (human recombinant)

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Cat No: 16102

Proteins - More Proteins

Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation.{23503} GDF11 is a circulating growth and differentiation factor that has age-dependent effe...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

bones related research cardiology aging neurosciences vascular diseases growths factors morphogenetic proteins developments developmental processes GDF-11 GDFs 11 BMP-11 BMPs differentiation brains vessels neural stems cells cardiac hypertrophy mesodermal skeletal neural tissues bone-related differentiation factor-11 growth growth-differentiation

Product Overview:
Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation.{23503} GDF11 is a circulating growth and differentiation factor that has age-dependent effects on development. Notably, injection of recombinant GDF11 into old mice, so that circulating levels match those in young mice, enhances vascularization in the brain, increases vessel volume, increases neural stem cell populations, and reverses cardiac hypertrophy.{26056,26403} These changes mimic the changes in vascular remodeling, neurogenesis, and olfactory function that are produced by providing young blood to aged mice.{26056,26403} In mouse embryos, GDF11 has critical roles in patterning mesodermal, skeletal, and neural tissues.{26405,26404,26406}

Size	10 µg
Shipping	dry ice
Formulation	Lyophilized
Purity	≥90% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.