A-7 (hydrochloride)

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A-7 (hydrochloride)

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Cat No: 16076

Biochemicals - Small Molecule Inhibitors

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function.{23723,23722} A-7 is an analog of the napthalenesulfonamide W-7 (Item No. ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(10-aminodecyl)-5-chloro-1-naphthalenesulfonamide, monohydrochloride

Correlated keywords:

80467-76-1 inhibitors signals transductions intracellular signaling signals inhibits inhibitions cell-permeable cells permeable antagonists As 7 A7 HCl potent Ca2+ cyclic nucleotide phosphodiesterase Ws 7 W7 W-7 calmodulin

Product Overview:
Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function.{23723,23722} A-7 is an analog of the napthalenesulfonamide W-7 (Item No. 14826) that has an acyl chain length of 10 carbons, rather than six. It is a potent cell-permeable antagonist of calmodulin that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7 (IC50 = 3.2 and 26 µM, respectively).{26195,26194}

Size	5 mg
Shipping	dry ice
CAS Number	79127-24-5
Molecular Formula	C₂₀H₂₉ClN₂O₂S • HCl
SMILES	O=S(C1=CC=CC2=C(Cl)C=CC=C21)(NCCCCCCCCCCN)=O.Cl
Molecular Weight	433,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.