CITCO

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CITCO

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Cat No: 16027

Biochemicals - Receptor Pharmacology

The constitutive androstane receptor (CAR) is a nuclear receptor that functions as a sensor of toxic compounds and enhances their elimination.{27663} CITCO is an agonist of human CAR (EC50 = 49 nM).{28128} It induces nuclear translocation of human CAR ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

O-[(3,4-dichlorophenyl)methyl]oxime 6-(4-chlorophenyl)-imidazo[2,1-b]thiazole-5-carboxaldehyde

Correlated keywords:

biochemical receptor agonist nuclear receptor gene regulation regulated cytochrome P450 cancer toxicology androstane CAR toxic translocation hepatocytes

Product Overview:
The constitutive androstane receptor (CAR) is a nuclear receptor that functions as a sensor of toxic compounds and enhances their elimination.{27663} CITCO is an agonist of human CAR (EC50 = 49 nM).{28128} It induces nuclear translocation of human CAR in hepatocytes, followed by increased expression of CAR-regulated genes, including several cytochrome P450 isoforms.{28128} CITCO less potently activates human pregnane X receptor (EC50 = 3 µM) and has no detectable activity on other nuclear receptors at 10 µM.{28128} It is selective for human CAR, whereas TCPOBOP (Item No. 14140) is selective for mouse CAR.{27663} CITCO does activate alternative splice variants of human CAR that are also found in liver cells.{28132} It is commonly used to study the action of human CAR in hepatocytes.{28130,28131}

Size	5 mg
Shipping	dry ice
CAS Number	338404-52-7
Molecular Formula	C₁₉H₁₂Cl₃N₃OS
SMILES	ClC1=CC=C(C2=C(/C=N/OCC3=CC(Cl)=C(Cl)C=C3)N4C(SC=C4)=N2)C=C1
Molecular Weight	436,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.