ERK Inhibitor

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ERK Inhibitor

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Cat No: 15944

Biochemicals - Kinase Inhibitors

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM).{25905} This prevents its interaction with protein substrates without inhibiting catalytic activity.{25905} ERK inhibitor blocks ERK-specific phosphorylati...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione, monohydrochloride

Correlated keywords:

294675-79-9 1438408-94-6 1438408-95-7 inhibitors cancers kinases proteins kinases intracellular signaling inhibits inhibitions cell-permeable cells permeable binds binder binding ERK2 ERK-2 ERKs 2 two docking domains blocks blocking phosphorylation prevents proliferation extracellular regulated ribosomal S6 kinase-1 kinase 1 ones Rsk-1 ternary complex factors Elk-1 Elk signals transduction 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione hydrochloride HCl

Product Overview:
ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM).{25905} This prevents its interaction with protein substrates without inhibiting catalytic activity.{25905} ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2.{25905} Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 µM), A549 lung carcinoma cells (IC50 = 25 µM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.{25905}

Size	500 µg
Shipping	dry ice
CAS Number	1049738-54-6
Molecular Formula	C₁₄H₁₆N₂O₃S • HCl
SMILES	CCOC1=CC=C(/C=C2SC(N(CCN)C\2=O)=O)C=C1.Cl
Molecular Weight	328,8
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.