3,3'-Diindolylmethane

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Cat No: 15927

Biochemicals - Small Molecule Inhibitors

3,3’-Diindolylmethane (DIM) is a bioactive metabolite of indole-3-carbinol, a phytochemical produced by the breakdown of the glucosinolate glucobrassicin found in cruciferous vegetables. At 10-30 µM, it demonstrates anticancer and chemopreventative ef...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,3'-methylenebis-1H-indole

Correlated keywords:

phytochemicals indole-3-carbinol indoles 3 three carbinol glucosinolate glucobrassicin cruciferous vegetables broccoli anticancers anti-cancer anti cancers chemoprevention Nrf2 Phase 2 enzymes apoptosis epigenetics radioprotectors radiomitigators antioxidants anti-oxidants oxidants intracellular signaling signals inhibitors inhibits inhibitions epigenetics DNAs damages repairs natural products transduction AhR agonists arundine HBs 236 HB236 HB-236 antiradiation anti-radiation chemopreventative metabolites cells cycles arrests proliferation histones deacetylases methylation Bis(3-indolyl)methane

Product Overview:
3,3’-Diindolylmethane (DIM) is a bioactive metabolite of indole-3-carbinol, a phytochemical produced by the breakdown of the glucosinolate glucobrassicin found in cruciferous vegetables. At 10-30 µM, it demonstrates anticancer and chemopreventative effects involving Nrf2 induction of Phase 2 enzymes, promotion of apoptosis, induction of cell cycle arrest, inhibition of cell proliferation, and inhibition of histone deacetylases and DNA methylation activities.{25951,25954,25953} Furthermore, at 0.3 µM DIM was shown to act as a potent radioprotector and mitigator of the effects of ionizing radiation exposure by stimulating an ATM-driven DNA damage-like response and NF-κB survival signaling in cultured epithelial cells.{25952}

Size	100 mg
Shipping	dry ice
CAS Number	04/05/1968 00:00
Molecular Formula	C₁₇H₁₄N₂
SMILES	C12=CC=CC=C1C(CC3=CNC4=C3C=CC=C4)=CN2
Molecular Weight	246,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.