2-Chloroadenosine

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2-Chloroadenosine

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Cat No: 15612

Biochemicals - Receptor Pharmacology

2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively.{19450} CADO has been used to activate adenosine receptors in the thalamus, ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-chloro-adenosine

Correlated keywords:

adenosines analogs receptors agonist A1 A2a A3 anticonvulsant neurosciences asthma cardiovascular chloro anti-convulsant anti convulsant 2-Cl-Ade 2-chloro-D-adenosine antibiotics ATs 265B NSCs 36896 NSC-36896 NSC36896 2 two 2a a 1 3 one three thalamus rats models seizures induces bronchoconstrictors guinea pigs normotensive hypertensive

Product Overview:
2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively.{19450} CADO has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures.{19452} It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats.{19453,19450}

Size	10 mg
Shipping	dry ice
CAS Number	146-77-0
Molecular Formula	C₁₀H₁₂ClN₅O₄
SMILES	O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(Cl)N=C3N)O[C@@H]1CO
Molecular Weight	301,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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