(Glp1)-Apelin-13 (trifluoroaceta

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(Glp1)-Apelin-13 (trifluoroacetate salt)

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Cat No: 15590

Biochemicals - Receptor Pharmacology

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Item No. 13524), apelin-17, and apelin-13 (Item No. 13523), respectively. Apelin-13 is an endogenous ligand of...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine, trifluoroacetate salt

Correlated keywords:

1462846-?06-?5 217082-60-5 receptors agonists hypertension vascular diseases neuroscience APJ Glp1 apelin 13 pyroglutamylated apelin 13 apelin-13 pyroglutamic acids plasma humans vasoconstricts vasoconstrictors antipyretic

Product Overview:
The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Item No. 13524), apelin-17, and apelin-13 (Item No. 13523), respectively. Apelin-13 is an endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.{18227,18228} (Glp1)-Apelin-13 is a pyroglutamylated form of apelin-13, in that the N-terminal glutamine residue is cyclized to pyroglutamic acid. Like apelin-13, this compound is a potent APJ receptor agonist (EC50 = 0.30 nM).{18227} (Glp1)-Apelin-13 is the major apelin isoform in the plasma of healthy human subjects.{25438} It can have vasoconstrictor and antipyretic effects in vitro and in vivo.{25437,25436,25439}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₆₉H₁₀₈N₂₂O₁₆S • XCF₃COOH
SMILES	O=C(N(CCC1)[C@@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C(NCC(N(CCC2)[C@@H]2C(N[C@@H](CCSC)C(N(CCC3)[C@@H]3C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)CC5=CNC=N5)=O)=O)=O)=O)[C@H](CCCNC(N)=N)NC([C@@H](N6)CCC6=O)=O.
Molecular Weight	1533,8
Formulation	A solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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