Formoterol (hemifumarate hydrate

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Formoterol (hemifumarate hydrate)

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Cat No: 15584

Biochemicals - Receptor Pharmacology

Formoterol is a selective agonist of the β2-adrenergic receptor (β2-AR; Kis = 7.58 and 2,630 nM for β2- and β1-ARs, respectively).{25444} It is selective for β-ARs in isolated guinea pig trachea over those in atrial tissue (pD2s = 9.29 and 6.98, respe...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

rel-N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-formamide, 2E-butenedioate (2:1), hydrate

Correlated keywords:

receptors agonists asthma neurosciences hemifumarates b-adrenergic beta-adrenergic .beta.-adrenergic adrenergic b beta .beta. ???-adrenergic obstructive pulmonary diseases allergy aformoterol atock BD40A BD 40A BD-40A CGP25827A CGP-25827A CGPs 25827A eformoterol foradil acrolizer certihaler NSCs 299587 NSC299587 NSC-299587 Oxis pMDi YMs 08316 YM08316 YM-08316 83536-10-1 87481-49-0 87833-61-2 43229-80-7

Product Overview:
Formoterol is a selective agonist of the β2-adrenergic receptor (β2-AR; Kis = 7.58 and 2,630 nM for β2- and β1-ARs, respectively).{25444} It is selective for β-ARs in isolated guinea pig trachea over those in atrial tissue (pD2s = 9.29 and 6.98, respectively) and has a long duration of action.{36701,25444} Aerosolized formoterol (10 µg/ml, inhaled) prevents the late asthmatic response and eosinophil and macrophage infiltration in bronchoalveolar lavage fluid (BALF), and as well as reduces bronchial reactivity in a guinea pig model of allergic asthma induced by ovalbumin.{36702} Formulations containing formoterol have been used, alone and in combination with other compounds, in the treatment of chronic obstructive pulmonary disease and asthma.{25441,25443,25440}

Size	10 mg
Shipping	dry ice
Molecular Formula	C₁₉H₂₄N₂O₄ • 1/2C₄H₄O₄ [XH₂O]
SMILES	COC1=CC=C(C[C@H](C)NC[C@@H](O)C2=CC(NC([H])=O)=C(O)C=C2)C=C1.OC(/C=C/C(O)=O)=O.COC3=CC=C(C[C@H](C)NC[C@@H](O)C4=CC(NC([H])=O)=C(O)C=C4)C=C3.O
Molecular Weight	402,5
Formulation	A solid
Purity	≥99%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.