ON-01910 (sodium salt)

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ON-01910 (sodium salt)

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Cat No: 15553

Biochemicals - Kinase Inhibitors

ON-01910 is a potent, non-ATP-competitive inhibitor of polo-like kinase 1 (Plk1; IC50 = 9 nM), a serine/threonine protein kinase involved in the regulation of cell cycling.{28096} It induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine, monosodium salt

Correlated keywords:

1225650-58-7 2542-59-1 592542-60-4 100873-86-3 1220287-17-1 ON01910 ONO01910Na estybon polo-like kinase 1 Plk1 Plk-1 multi-drug intra-peritoneally ON-01910.Na ON01910.Na ON-01910Na ON01910Na ON-01910-Na ON01910-Na ON-019190.Na ON019190.Na ON-019190Na ON019190Na ON-019190-Na ON019190-Na ON-0910.Na ON0910.Na ON-0910Na ON0910Na ON-0910-Na ON0910-Na ON-1910.Na ON1910.Na ON-1910Na ON1910Na ON-1910-Na ON1910-Na ON-19190.Na ON19190.Na ON-19190Na ON19190Na ON-19190-Na ON19190-Na ON-910.Na ON910.Na ON-910Na ON910Na ON-910-Na ON910-Na

Product Overview:
ON-01910 is a potent, non-ATP-competitive inhibitor of polo-like kinase 1 (Plk1; IC50 = 9 nM), a serine/threonine protein kinase involved in the regulation of cell cycling.{28096} It induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200 nM) and blocks the growth of multidrug resistant cancer cell lines.{28096,28095,28097,28098} ON-01910 is active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents, preventing tumor growth or abolishing tumors in human xenograft nude mouse models.{28096}

Size	1 mg
Shipping	dry ice
CAS Number	1225497-78-8
Molecular Formula	C₂₁H₂₅NO₈S • Na
SMILES	COC1=CC=C(CS(/C=C/C2=C(OC)C=C(OC)C=C2OC)(=O)=O)C=C1NCC([O-])=O.[Na+]
Molecular Weight	473,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.