Platensimycin

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Platensimycin

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Cat No: 15507

Biochemicals - Natural Products

Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM).{25106} It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an en...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[[3-[(1S,3S,4S,9S)-1,4,5,8,9,9aR-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5aS-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-benzoic acid

Correlated keywords:

898249-?77-?9 1016964-?67-?2 PTM antibiotics type 2 fatty acids biosynthesis drugs resistances antibacterial anti bacterial bacteria anti-bacterial FabF diabetes ACP beta-ketoacyl-acyl-carrier-protein synthase I/II selective S. platensis grams gram-positive positive biosynthesis mammalian liver triglyceride insulin diabetes diabetic natural metabolic syndrome infectious disease (-)

Product Overview:
Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM).{25106} It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively).{25106} By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance.{25108} PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg.{25107}

Size	250 µg
Shipping	dry ice
CAS Number	835876-32-9
Molecular Formula	C₂₄H₂₇NO₇
SMILES	O=C(O)C1=C(O)C(NC(CC[C@@]2(C)[C@@]([C@](O3)([H])C[C@]([H])(C4)[C@]3(C)C5)([H])[C@]54C=CC2=O)=O)=C(O)C=C1
Molecular Weight	441,5
Formulation	A solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.