CBX3 (human recombinant)

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Cat No: 15467

Proteins - More Proteins

The heterochromatin protein 1 (HP1) family, which consists of isoforms HP1-α (CBX5), HP1-β (CBX1), and HP1-γ (CBX3), are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal ch...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

epigenetics chromodomains CSD CBX chromobox histones 3 H3K9me3 proteins recombinant homologs 3 three HECH heterochromatin 1 one gamma .gamma. g ? HP1 modifiers 2 two HP1? HP1.gamma. HP1gamma HP1g genes regulations formations methylated H3 lysine 9 nine H1 26 H1K26me G9A 185 Nanog genes transcriptions HIV-1 tumors stems cells osteosarcoma

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The heterochromatin protein 1 (HP1) family, which consists of isoforms HP1-α (CBX5), HP1-β (CBX1), and HP1-γ (CBX3), are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain, and a hinge domain that connects the two.{23468} Extensive post-translational modifications have been observed and mapped on the CBX proteins.{23471} The chromodomain of CBX3 has been shown to recognize methylated histone H3 lysine 9, methylated histone H1 lysine 26, and G9A methylated at lysine 185.{25450} CBX3 associates with the exons of a subset of actively transcribed genes, and loss of CBX3 results in accumulation of unspliced mRNA from that subset of genes.{25452,25453} Further, CBX3 suppresses Nanog gene transcription in pre-induced pluripotent stem cells and long terminal repeat protein expression in HIV-1 infected cells.{25453,25449} Knockdown of CBX3 by siRNA in cells latently infected with HIV-1 leads to virus reactivation.{25448} CBX3 has been proposed to be a biomarker for tumor stem cells in osteosarcoma.{25451}

Size	100 µg
Shipping	dry ice
Formulation	50 mM Tris, pH 7.4, containing 150 mM sodium chloride and 20% glycerol
Purity	≥95% (estimated by SDS-PAGE)
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.