Nobiletin

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Nobiletin

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Cat No: 15421

Biochemicals - Lipids

Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.{52725,52726,52727} It reduces LPS- and IFN-γ-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one

Correlated keywords:

natural products antioxidants cancers arthritis neurosciences inflammation oxidative injury inhibitors inhibits polymethoxylated flavonoids citrus fruits peels antioxidant anti-oxidant anti oxidants anti-inflammatory antiinflammatory inflammatory cancers arthritis neurodegeneration ATP-binding cassettes ABC proteins resistance NSCs 618903 76751 NSC618903 NSC76751 NSC-618903 NSC-76751 bioavailability diseases ATP binding P-glycoprotein Ps glycoproteins breasts B-16 A-5 549

Product Overview:
Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.{52725,52726,52727} It reduces LPS- and IFN-γ-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM.{52725} Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC50 values of 22, 18, 13, and 8.3 µM, respectively.{52726} Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks.{52727} It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.

Size	5 mg
Shipping	dry ice
CAS Number	478-01-3
Molecular Formula	C₂₁H₂₂O₈
SMILES	O=C1C2=C(OC)C(OC)=C(OC)C(OC)=C2OC(C3=CC=C(OC)C(OC)=C3)=C1
Molecular Weight	402,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.