Miconazole (nitrate)

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Cat No: 15420

Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14α-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes.{24644,23407} Additionally, miconazole has been s...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole, mononitrate

Correlated keywords:

75319-?47-?0 22916-47-8 75319-?48-?1 antifungals antimycotic fungicides azoles inhibitors ergosterol synthesis biofilms ROS reactive oxygen species Candida anti-fungals fungals anti mycotic anti-mycotic nitrates imidazoles agents aflorix albistat andergin creams brentan conoderm conofite doctrines daktar daktarin deralbine dermonistat ecobi epi-monistat epi monistat florid fungiderm fungisdin gyno-daktarin gyno daktarin gyno-monistat hi-pick hi pick hipick loptrimin AF jock itch jock-itch jockitch powders aerosols lotrimin sprays liquids micatin miconal miconaz micotef ministat suppositories derm NSCs 169434 NSC-169434 NSC169434 priconazole prilagin Rs 14889 R-14889 R14889 vodol zeasorb zimycan inhibiting inhibitions 14?-demethylation 14? demethylation 14.alpha.-demethylation 14alpha-demethylation 14.alpha. 14alpha lanosterol ergosterol cells membranes induces inductions MIC nitrate

Product Overview:
Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14α-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes.{24644,23407} Additionally, miconazole has been shown to induce reactive oxygen species in fungal biofilms, demonstrating a MIC value of ≥256 μM against Candida spp.{25332}

Size	1 g
Shipping	dry ice
CAS Number	22832-87-7
Molecular Formula	C₁₈H₁₄Cl₄N₂O • HNO₃
SMILES	ClC1=CC(Cl)=CC=C1COC(C2=C(Cl)C=C(Cl)C=C2)CN3C=NC=C3.[O-][N+](O)=O
Molecular Weight	479,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.