Roquefortine C

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Roquefortine C

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Cat No: 15376

Biochemicals - Small Molecule Inhibitors

Roquefortine C is a mycotoxin that was first isolated from a strain of P. roqueforti, a species of Penicillium commercially used to ripen blue-veined cheeses.{24904} It has also been isolated from other members of the Penicillium genus found in contam...

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Territorial Availability: Available through Bertin Technologies only in France

                                            Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
                    

                        Special Advice: Please check regulation status before ordering; additionel fees can apply. 
                    

Synonyms:

(3E,5aS,10bR)-10b-(1,1-dimethyl-2-propen-1-yl)-6,10b,11,11aS-tetrahydro-3-(1H-imidazol-5-ylmethylene)-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione

Correlated keywords:

56832-?54-?3 natural products metabolites mycotoxins Penicillium neurotoxins penitrem A toxins P. roqueforti food contaminated P-glycoproteins xenobiotics cytochrome P450 3A biomarkers intoxication toxicology neurosciences NSCs 292134 NSC292134 NSC-292134

Product Overview:
Roquefortine C is a mycotoxin that was first isolated from a strain of P. roqueforti, a species of Penicillium commercially used to ripen blue-veined cheeses.{24904} It has also been isolated from other members of the Penicillium genus found in contaminated food products where it displays neurotoxic properties.{24905} It has been shown to both activate a P-glycoprotein transport system involved in the efflux of xenobiotics and to inhibit cytochrome P450 3A detoxification enzymes.{24907} It has also been used as a biomarker for penitrem A (Item No. 11347) intoxication.{24906}

Size	500 µg
Shipping	dry ice
CAS Number	58735-64-1
Molecular Formula	C₂₂H₂₃N₅O₂
SMILES	CC([C@]12C3=CC=CC=C3N[C@]1(N([C@@]([H])(C2)C(N/4)=O)C(C4=C/C5=CN=CN5)=O)[H])(C=C)C
Molecular Weight	389,5
Formulation	A solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.