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1-Aminobenzotriazole

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    1-Aminobenzo<wbr/>triazole
  • 1-Aminobenzo<wbr/>triazole
Cat No: 15252
Biochemicals - Small Molecule Inhibitors
Cayman

1-aminobenzotriazole (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.{32434,32435,24115} It does not appear to affect other enzymes, including UDP-glucuronosyltransferases.{32436,20875} ABT acts as a CYP suicide substrate, producing maximal de...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 1H-benzotriazol-1-amine
Correlated keywords:
  • UDP CYP substrate hepatic NSC114498 NSC656987 benzotriazolylamine amino benzotriazole
Product Overview:
1-aminobenzotriazole (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.{32434,32435,24115} It does not appear to affect other enzymes, including UDP-glucuronosyltransferases.{32436,20875} ABT acts as a CYP suicide substrate, producing maximal destruction of hepatic and renal microsome CYP protein in vitro at 10 mM.{32436} It is effective in vivo, significantly reducing CYP content in both liver and kidney in rats within two hours.{32436} The effects of ABT on CYP activity is time-dependent, with significant shift in IC50 values with preincubation.{24115}
Size 50 mg
Shipping dry ice
CAS Number 1614-12-6
Molecular Formula C6H6N4
SMILES NN1C2=CC=CC=C2N=N1
Molecular Weight 134,1
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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