Amiodarone (hydrochloride)

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Cat No: 15213

Biochemicals - Ion Channel Modulation

Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value o...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride

Correlated keywords:

1951-25-3 inhibitors cardiology vascular diseases channels blockers ions antiarrhythmic agents anti-arrhythmic anti arrhythmic potassium currents blocks blockage hERG voltage-gated voltages gated KCNH2 amiodar HCl aminodaronum ancoron angiodarona atlansil cordarex cordarone X cordarone-X Ls 3428 L3428 L-3428 3428 labaz miocard miodaron ortacrone pacerone ritmocardyl rythmarone SKFs 33134A SKF33134A SKF-33134A trangorex cardiac actions potentials sigma-1 opioid receptors 3-?-hydroxysteroid ?8?7 isomerase 3-.beta.-hydroxysteroid .DELTA. 8 7 DELTA 3-beta-hydroxysteroid C-8 sterol isomerase thyroid hormones .alpha. .beta. ? ? cytochrome P450 CYPs CYP2C8 CYP3A4

Product Overview:
Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6, 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}

Size	500 mg
Shipping	dry ice
CAS Number	19774-82-4
Molecular Formula	C₂₅H₂₉I₂NO₃ • HCl
SMILES	IC1=C(OCCN(CC)CC)C(I)=CC(C(C2=C(CCCC)OC3=C2C=CC=C3)=O)=C1.Cl
Molecular Weight	681,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.