ML-289

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ML-289

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Cat No: 15195

Biochemicals - Receptor Pharmacology

Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites within the receptor are being developed to prefere...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

[3R-(hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone

Correlated keywords:

molecular library libraries initiative VU0463597 VUs 0463597 VU-0463597 negative allosteric modulators NAM mGlu3 glutamates metabotropic receptors mGluRs mGlus mGlu-3 three 3 MLs ML289 289 excitatory neurotransmitter CNS activates selective sites target pharmacological roles ML-298 15-fold 15 folds selectivity mGlu2 mGlu-2 2 two inactivity mGlu5 mGlu-5 5 five

Product Overview:
Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites within the receptor are being developed to preferentially target individual mGluR subtypes in order to determine their distinct pharmacological roles. ML-298 is a negative allosteric modulator of mGlu3 (IC50 = 0.66 μM) that displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.{24539}

Size	1 mg
Shipping	dry ice
CAS Number	1382481-79-9
Molecular Formula	C₂₂H₂₃NO₃
SMILES	COC1=CC=C(C#CC2=CC=C(C(N3C[C@H](CO)CCC3)=O)C=C2)C=C1
Molecular Weight	349,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.