CYM 5541

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CYM 5541

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Cat No: 15190

Biochemicals - Receptor Pharmacology

The sphingosine 1-phosphate (S1P) receptor S1P3 has roles in vasodilation, epithelial barrier function, cardioprotection, fibrosis, immunity, and inflammation.{16449,24542} CYM 5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM).{24544,2...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N,N-dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

Correlated keywords:

receptors agonists diseases cardiology immunology inflammation signals transductions sphingosine-1-phosphates S1P sphingosines 1 phosphates S1P3 allosteric S1P1 ion channels transporters ceramides sphingolipids vascular ML249 MLs 249 CIDs CID-17253208 CID17253208 CYM-5541 CYMs 5541 1-phosphates roles vasodilation epithelial barriers functions cardioprotection fibrosis immunity selective activates S1P2 S1P4 S1P5 ML-249

Product Overview:
The sphingosine 1-phosphate (S1P) receptor S1P3 has roles in vasodilation, epithelial barrier function, cardioprotection, fibrosis, immunity, and inflammation.{16449,24542} CYM 5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM).{24544,24543} It less effectively activates S1P1 (EC50 = 28-38 µM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters.{24544}

Size	5 mg
Shipping	dry ice
CAS Number	945128-26-7
Molecular Formula	C₁₉H₂₈N₂O₂
SMILES	O=C(N(C1CCCCC1)C2CCCCC2)C3=NOC(C4CC4)=C3
Molecular Weight	316,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.