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ML-161

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    ML-<wbr/>161
  • ML-<wbr/>161
Cat No: 15179
Biochemicals - Receptor Pharmacology
Cayman

ML-161 is an allosteric, reversible inhibitor of proteinase-activated receptor 1 (PAR1) on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 µM.{24559} It blocks platelet activation induced...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-benzamide
Correlated keywords:
  • inhibitors receptors antagonists biochemistry vascular diseases signals transductions reversible inhibits inhibitions PAR1 PARs 1 one PAR-1 PAR1-mediated mediated platelets activations active activates protease-activated proteases platelets P-selectin Ps selectins peptides SFLLRN thrombin MLs 161 ML161 AG-670 AGs 670 AG670 CIDs 1048267 CID-1048267 CID1048267
Product Overview:
ML-161 is an allosteric, reversible inhibitor of proteinase-activated receptor 1 (PAR1) on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 µM.{24559} It blocks platelet activation induced by thrombin as well as by SFLLRN but not by PMA (Item No. 10008014), U-46619 (Item No. 16450), or collagen.{24559}
Size 1 mg
Shipping dry ice
CAS Number 423735-93-7
Molecular Formula C17H17BrN2O2
SMILES BrC1=C(C(NC2=CC=CC(NC(CCC)=O)=C2)=O)C=CC=C1
Molecular Weight 361,2
Formulation A crystalline solid
Purity ≥95%
Custom Code 2903.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : ML-<wbr/>161 There are 4 products.

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