Vitexin

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Vitexin

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Cat No: 15116

Biochemicals - Natural Products

Vitexin is an apigenin flavone C-glycoside isolated from Crataegus spp. (hawthorn), Passiflora spp. (passionflower), P. glaucum R. Br. (pearl millet), P. nigra (bamboo leaves), V. agnuscastus L. (chasteberry), and various other tropical plant species....

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

8-?-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Correlated keywords:

521-33-5 30108-44-2 53152-13-9 55555-34-5 antioxidant anti-oxidant anti oxidant antiinflammatory inflammatory anti-nociceptive nociceptive anti-inflamamtory antinociceptive apigenin falvone C-glycoside natural product inhibitors inhibits inhibitions tumors antitumors anti-tumor apoptosis C-glycosides C glycosides crataegus spp. Hawthorn passiflora spp passion flowers P. glaucum R. Br. Pearl millet P. nigra bamboo leaves. V. agnuscatus L. chasteberry tropical plants species carbohydrate hydrolyzing enzymes cancer xenograft TRPV1 apigenin flavones Isovitexin C-8 isomers C8 Cs 8 eight orientoside vitexina vitexine natural flavonoids immunology pains cancers apoptosis

Product Overview:
Vitexin is an apigenin flavone C-glycoside isolated from Crataegus spp. (hawthorn), Passiflora spp. (passionflower), P. glaucum R. Br. (pearl millet), P. nigra (bamboo leaves), V. agnuscastus L. (chasteberry), and various other tropical plant species.{24173,24171,24172} It demonstrates antioxidant activity in a DPPH bleaching assay (IC50 = 24.2 μM) and also inhibits the activity of the carbohydrate-hydrolyzing enzyme α-glucosidase (IC50 = 244 μM).{24173,24172} It has been shown to have broad anti-tumor activity, activating caspases and inducing apoptosis in cancer xenograft models.{24170} Additionally, vitexin at 10 mg/kg exhibits an analgesic effect in several different models of inflammatory pain by targeting TRPV1 channel activity, by preventing the decrease of reduced glutathione levels, and by modulating the production of cytokines.{24169}

Size	5 mg
Shipping	dry ice
CAS Number	3681-93-4
Molecular Formula	C₂₁H₂₀O₁₀
SMILES	O=C1C=C(C2=CC=C(O)C=C2)OC3=C([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(O)=CC(O)=C31
Molecular Weight	432,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.