Wiskostatin

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Wiskostatin

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Cat No: 15047

Biochemicals - Small Molecule Inhibitors

Wiskott-Aldrich syndrome proteins (WASPs) regulate the actin cytoskeleton by directly interacting with actin in the Arp2/3 complex.{23890} As a result, they have essential functions in diverse cellular processes, including phagocytosis, cell motility, ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,6-dibromo-?-[(dimethylamino)methyl]-9H-carbazole-9-ethanol

Correlated keywords:

cytoskeletal researchs neurosciences cells biology WASPs wiskott-aldrich wiskott Aldrich syndromes proteins cell-permeable cells permeable inhibitors inhibits inhibitions neural n-WASPs GTPase-binding GTPase-binding binds binder Cdc42 Cdc-42 Cdc 42 PIP2 phosphatidylinositol 4,5-bisphosphate transports endocytosis neurological developments regulates actins cytoskeletons Arp2/3 complex Arp 2/3 cellular processes phagocytosis motility membranes trafficking wiskostatin selectives activations domains

Product Overview:
Wiskott-Aldrich syndrome proteins (WASPs) regulate the actin cytoskeleton by directly interacting with actin in the Arp2/3 complex.{23890} As a result, they have essential functions in diverse cellular processes, including phagocytosis, cell motility, and membrane trafficking.{23889} Wiskostatin is a cell-permeable, selective inhibitor of neural WASP (N-WASP, IC50 = ~10 μM).{23889} It directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate.{23889} By inhibiting N-WASP, wiskostatin interferes with membrane transport, endocytosis, and neurological development.{23891,23887,23888}

Size	1 mg
Shipping	dry ice
CAS Number	253449-04-6
Molecular Formula	C₁₇H₁₈Br₂N₂O
SMILES	OC(CN(C)C)CN1C2=CC=C(Br)C=C2C3=C1C=CC(Br)=C3
Molecular Weight	426,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.