Mibefradil (hydrochloride)

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Cat No: 15037

Biochemicals - Ion Channel Modulation

Mibefradil is a general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 μM, respectively).{23964,23965,23967} It is a potent vasodilator, increasing coronary artery flow with an EC50 ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester 2-methoxy-acetic acid, dihydrochloride

Correlated keywords:

116644-53-2 121039-16-5 153127-38-9 ions channels blockers hypertension vascular diseases calcium T-type T types L-type L HCl inotropic anti-hypertensive agents anti hypertensive antihypertensive RO 40-5967/001 40-5967 405967 40 5967 Ro405967 Ro40-5967 Ro40 Ro-40-5967 Ro-405967 Ro-40 mibefradil selectivity vasodilator coronary artery flow effects

Product Overview:
Mibefradil is a general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 μM, respectively).{23964,23965,23967} It is a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM.{23965} Mibefradil has minimal negative inotropic effects, supporting its use as an anti-hypertensive agent.{23965,23966}

Size	5 mg
Shipping	dry ice
CAS Number	116666-63-8
Molecular Formula	C₂₉H₃₈FN₃O₃ • 2HCl
SMILES	CN(CCCC1=NC2=C(C=CC=C2)N1)CC[C@]([C@H]3C(C)C)(CCC4=CC(F)=CC=C34)OC(COC)=O.Cl.Cl
Molecular Weight	568,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.