Tolterodine (tartrate)

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Cat No: 15027

Biochemicals - Receptor Pharmacology

Tolterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively).{22772} It reduces intracellular calcium mobilization induced by carbachol (carbamoylcholine; Item No. 14486) in...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenol, 2R,3R-dihydroxybutanedioate

Correlated keywords:

124937-51-5 Receptors antagonists neurosciences muscarinic M M1 M2 M3 M4 M5 M-1 M-2 M-3 M-4 M-5 1 2 3 4 5 overactive over active over-active bladders Detrol L-tartrate L- L detrusitol PNUs 200583E 200583 200583-E E PNU200583E 200583 PNU-200583-E PNU200583E PNU200583 PNU200583-E terol tolterodine acids tolterodinium Detrol LA

Product Overview:
Tolterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively).{22772} It reduces intracellular calcium mobilization induced by carbachol (carbamoylcholine; Item No. 14486) in bladder smooth muscle cells and submandibular gland cells isolated from cynomolgus monkeys (Kis = 3.16 and 2 nM, respectively).{39587} Tolterodine inhibits volume-induced bladder contractions and oxotremorine-induced salivation in rats (ID50s = 0.025 and 0.12 mg/kg, respectively).{39586} Formulations containing tolterodine have been used in the treatment of overactive bladder.

Size	10 mg
Shipping	dry ice
CAS Number	124937-52-6
Molecular Formula	C₂₂H₃₁NO • C₄H₆O₆
SMILES	OC1=C([C@@H](C2=CC=CC=C2)CCN(C(C)C)C(C)C)C=C(C)C=C1.O[C@H]([C@@H](O)C(O)=O)C(O)=O
Molecular Weight	475,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.