?-Lapachone

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?-Lapachone

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Cat No: 15021

Biochemicals - Small Molecule Inhibitors

β-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 μM and transglutaminase (IC50 = 5 μM).{22728,22726} In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, β-lapachon...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione

Correlated keywords:

natural products inhibitors inhibits inhibitions inflammation cancers apoptosis quinones anti-cancers anticancers anti anti-inflammatory antiinflammatory inflammatory antiinflammation anti-inflammation effects topoisomerases I transglutaminases cells cellular overexpress overexpressions NAD(P)H:quinone NADPH:quinone oxoreductases NQO1 b-lapachone beta-lapachone .beta.-lapachone lapachones .beta. beta b ? hydroquinones reactive oxygens species ROS reversions senstizes radiation suppresses suppression NF-?B activations ROS ARQ 501 ARQ-501 ARQ501 NSCs 26326 629749 NSC-26326 NSC-629749 NSC26326 NSC629749 SLs 1101 SL-11001 SL1101 nuclear factors kappa-light-chain-enhancer activated B transcriptions

Product Overview:
β-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 μM and transglutaminase (IC50 = 5 μM).{22728,22726} In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, β-lapachone is reduced to β-lapachone hydroquinone, which generates reactive oxygen species during its reversion to β-lapachone.{22729} This process sensitizes cancer cells to radiation, suppresses NF-κB activation, and drives apoptosis.{22729,22725,22727}

Size	5 mg
Shipping	dry ice
CAS Number	4707-32-8
Molecular Formula	C₁₅H₁₄O₃
SMILES	O=C(C1=C(C2=C3CCC(C)(C)O2)C=CC=C1)C3=O
Molecular Weight	242,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.