PF-04981517

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PF-04981517

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Cat No: 15019

Biochemicals - Small Molecule Inhibitors

PF-04981517 is a potent, time-dependent inhibitor of the cytochrome P450 (CYP450) isoform CYP3A4 (IC50 = 30 nM).{22614} It is less effective against CYP3A5 and CYP3A7 (IC50s = 17 and 70 μM, respectively).{22614} PF-04981517 will be useful for understa...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-(1-piperidinyl)-1-pyrrolidinyl]-1H-pyrazolo[3,4-d]pyrimidine

Correlated keywords:

inhibitors toxicology drugs metabolisms inhibits inhibitions PF-04981517 PF04981517 PFs 04981517 PF-4981517 PF4981517 4981517 cytochromes CYPs CYP450 CYP3A4 CYP3A7 drugs roles relative isozymes 450 3A4 3A7 drug-metabolizing enzymes time-dependent

Product Overview:
PF-04981517 is a potent, time-dependent inhibitor of the cytochrome P450 (CYP450) isoform CYP3A4 (IC50 = 30 nM).{22614} It is less effective against CYP3A5 and CYP3A7 (IC50s = 17 and 70 μM, respectively).{22614} PF-04981517 will be useful for understanding the relative roles of CYP3A4 and CYP3A5 in drug metabolism.

Size	5 mg
Shipping	dry ice
CAS Number	1390637-82-7
Molecular Formula	C₂₆H₃₂N₈
SMILES	CC1=CC=C(C2=C(C3=NN(C)C4=C3C(N5C[C@@H](N6CCCCC6)CC5)=NC=N4)C=NN2C)C=C1
Molecular Weight	456,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.