Sp-Cyclic AMPS (sodium salt)

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Cat No: 14983

Biochemicals - More Biochemicals

Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases.{24263} Sp-c...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

cyclic 3',5'-[hydrogen (S)-phosphorothioate] adenosine, monosodium salt

Correlated keywords:

71774-13-5 cAMPs analogs phosphodiesterases PDE10 PDEs PDE-10 10 ten GAF domains cGMP adenylyl cyclases guanylyl cGMP-specific stimulated phophodiesterases Anabaena Escherichia coli FhIA nucleototides derivatives SpcAMPS Sp cAMPS binds binding binders stimulations cAMPS phosphatases intracellular signals transductions

Product Overview:
Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases.{24263} Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC50 = 40 μM).{24263} It has been used to study GAF-mediated stimulation of PDE10.{24263}

Size	1 mg
Shipping	dry ice
CAS Number	142439-95-0
Molecular Formula	C₁₀H₁₁N₅O₅PS • Na
SMILES	[S-][P@]1(OC[C@]2([H])[C@@]([C@@H](O)[C@H](N3C(N=CN=C4N)=C4N=C3)O2)([H])O1)=O.[Na+]
Molecular Weight	367,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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