Furin Inhibitor I

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Furin Inhibitor I

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Cat No: 14965

Biochemicals - Small Molecule Inhibitors

Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, i...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N2-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-lysinamide

Correlated keywords:

decanoyl-Arg-Val-Lys-Arg-CMK decanoyl-Arg-Val-Lys-Arg-chloromethylketone dec-RVKR-CMK TACE decanoyl Arg Val Lys Arg CMKs chloromethylketones chloromethyl ketones chloro methyl inhibitors inhibits inhibitions decanoyl RVKR dec decanoyl-RVKR- dec-CMK furins proproteins pro-proteins pro proteins convertases antiviral inflammation anti-viral anti viral inhibitor-1 1 one selective irreversible cell-permeable cells permeable SPCs SPC1 SPC-1 SPC2 SPC-2 PC2 PC-2 PCs 2 two SPC2/PC2 SPC3 SPC-3 3 three PC3 PC-3 SPC3/PC1/PC3 PC-1 PC1 SPC4 SPC-4 four 4 PACE4 PACEs PACE-4 SPC4/PACE4 SPC-6 6 six SPC6 PC5 PC-5 five 5 PC6 PC-6 SPC6/PC5/PC6 SPC7 SPC-7 seven 7 LPCs PC7 PC-7 PC8 PC-8 8 eight SPC/LPC/PC7/PC8 inflammatory MMPs MMP-2 MMP2 infectious diseases biology competetive glycoproteins pro-MMP-2

Product Overview:
Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM).{24090,24089} Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent.{24087} In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells.{24088}

Size	500 µg
Shipping	dry ice
CAS Number	150113-99-8
Molecular Formula	C₃₄H₆₆ClN₁₁O₅
SMILES	O=C([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCC)=O)CCCNC(N)=N)=O)C(C)C)=O)CCCCN)N[C@@H](CCCNC(N)=N)C(CCl)=O
Molecular Weight	744,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.