24-dehydro Cholesterol

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24-dehydro Cholesterol

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Cat No: 14943

Biochemicals - Lipids

24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellula...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?)-cholesta-5,24-dien-3-ol

Correlated keywords:

steroids sterols precursors biosynthesis cholesterol desmosterolosis LXR foams cells macrophages lipids metabolism membranes Bloch pathways biosynthesis liver X receptors targets genes atherosclerotic atherosclerosis nuclear receptors neurosciences intracellular signals signaling oxysterols immediates NSCs 226126 NSC-226126 NSC226126 brains 24,25-Dehydrocholesterol 24-dehydrocholesterol dehydrocholesterol

Product Overview:
24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies.{26099} During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols.{26098} However, defects in cholesterol synthesis can lead to a condition called, desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol.{26100} 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.{26096,26097}

Size	1 mg
Shipping	dry ice
CAS Number	313-04-2
Molecular Formula	C₂₇H₄₄O
SMILES	C/C(C)=C/CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Molecular Weight	384,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2906.13
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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